George Weaver was born in Louisville Kentucky and became interested in horse racing at a young age. In high school he worked as a hot walker for John Henning before working as a foreman for D. Wayne Lukas. He worked his way up to assistant for Lukas and developed horses such as Kentucky Derby winners Grindstone and Thunder Gulch, Preakness winners Timber Country and Tabasco Cat, Serena’s Song, and Grand Slam amongst others.

Weaver then became an assistant trainer to Todd Pletcher in 1997 and during a six-year period worked with horses like Trippi, More Than Ready, Texas Glitter, and Left Bank. In 2002, Weaver went out on his own. Most recently George conditioned the Grade 1 Winner and now stallion, Vekoma.